Detoxification

Glutathione is as important to your cells as oxygen, food or water to survive. Glutathione is the master ‘Guardian of the Cell.’ It’s our life force in the following ways:

• It is the maestro of the immune system in your cells
• Significantly decreases inflammation
• Removes toxins from your cells
• Neutralizes free radicals
• Fuels ATP production

“In any given second there are tens of thousands of chemical and electrical reactions occurring inside our cells. Glutathione is a key factor in directly supporting many of those reactions as well as neutralizing free radicals and escorting toxins out of the cell. It is called the ‘Guardian of the Cell’ for good reason.” Dr. Davidson


 
How does Glutathione body detoxification protect us from the various toxins?

There is no simple answer.

Basically it protects us in two ways. One, it detoxifies or helps remove toxins when they enter the body and subsequently the individual cells in the organs. So after the attack it goes to work removing the toxins.

When a person overdoses on Tylenol, in the hospital ED or ER Doctor will administer a glutathione precursor that promotes the production of Glutathione.

Daily we are attacked by enemy insurgents. The intercellular glutathione body detoxification is one of the body’s most important defense systems. Unfortunately few even know of it.

Scientific studies have shown that glutathione (GSH) has multiple detoxification functions. Depletion of glutathione is associated with increased risk of chemical toxicity.

With so many man-made chemicals being released into the atmosphere and waterways, and added to foods and medications, you might wonder whether or not your body even knows what to do with such harsh materials when it comes into contact with them. After all, many of these toxic chemicals do not occur in nature, but are manufactured in the lab. Fortunately, your body has a natural, inborn detoxification system that relies primarily on glutathione for its activation and operation.

Glutathione is one of your body’s primary antioxidants. It is utilized by virtually every cell in your body, in its cellular enzymatic state (glutathione reductase), to maintain the cell’s healthy (redox) state and prevent the proliferation of harmful free radicals. Naturally, to aid detoxification, glutathione levels are highest in the liver and kidneys, which are the body’s primary detoxification organs.

Glutathione is more necessary than ever due to the environment in which most people live. Scientists have counted over 80,000 foreign chemicals in the foods people ingest and the air that is breathed. Without glutathione, all of these toxins can enter the body's cells and play havoc with their health.

Some of the most dangerous of the toxins that can enter the body are heavy metals. Fortunately, glutathione can remove heavy metals from the body's cells through a process called chelation.

Toxins also break down mitochondrial DNA within the cells. This causes rapid aging and premature cellular death. Glutathione creates a protective barrier that increases the strength of mitochondrial DNA. Through the same action, glutathione also protects another vulnerable part of the body's cells: the nucleus.

Another intracellular benefit of glutathione is the elimination of free radicals. As the most powerful natural antioxidant, glutathione plays a major role in reducing free radical damage.

RiboCeine™ is an advanced compound that effectively delivers the key precursor nutrient into the cell that enables it to produce optimal amounts of glutathione. It is designed to effectively protect and deliver the fragile cysteine molecule to the cell. Cysteine is often in limited supply in the body but is an essential component needed for the production of gluatathione. Glutathione is especially important due to its unique ability to protect the cell, the very place where ATP is manufactured. RiboCeine™ also delivers ribose, a natural compound required for the production of ATP, the basic form of cellular energy in the body. More cysteine leads to more glutathione and a strengthened cellular defense that benefits the entire body. And, RiboCeine™ is shown to be 300% more effective than NAC (N-acetyl-l-cysteine) in raising liver glutathione levels.

Unlike any other nutritional compound in the world, RiboCeine™ has been the subject of twenty published, peer-reviewed scientific studies that were funded by the National Institute of Health and other scientific institutions and has significantly outperformed all other means of glutathione enhancement against which it has been tested.



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Overview - Real Science you can see and feel

"I have never seen a company more focused on scientific anvancement than Max International - Dave Bagley, CEO"

Committed to developing real health breakthroughs based on scientific research Max International leads the wellness and nutritional industry in delivering quality proprietary products. Through the efforts of renowned medicinal chemist Dr. Herbert T. Nagasawa and other experts Max International has developed groundbreaking advances in glutathione enhancing products.






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Scientist from the University of Minnesota Have Created a Patented Breakthrough in Cellular Protection that Will Change your Life!

When you're looking for real results, you rely on research that you can trust. Max International's breakthrough products are the result of decades of dedicated research and development.

This work was driven by one man, Dr. Herbert T. Nagawsawa. A celebrated research scientist and a distinguished professor of pharmacology, toxicology, and medicinal chemistry, Dr. Nagasawa worked tirelessly in his nearly found decade career to find better ways to improve the body's health and performance.

The work of Dr. Nagasawa's team of researchers focused on one very important component of our bodies: glutathione. He knew that glutathione was capable of providing extraordinary health improvements and, after years of research, Dr. Nagasawa and his team had "Eureka" moment - they had developed the breakthrough compound known today as RiboCeine.

By combining two naturally occurring nutrients into a new molecule, Dr. Nagasawa found that RiboCeine could effectively raise glutathione levels 300% more effectively than NAC (N-acetly-l-cysteine) in raising liver gluathione levels.* In fact, continued research demonstrated that RiboCeine enabled cells throughout the body to increase their production and levels of glutathione. For more than two decades, his team and research scientists at other universities and institutions studied the extraordinary benefits of raising glutathione levels using RiboCeine. *Published in Roberts, J.C., Nagasawa, H.T., et al. (1987) Prodrugs of L-Cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2- (polyhydroxyalkly)- and 2-(Polyhydroxyalky)-Thiazolidine-4(R)-Carboxylic Acids. In Journal of Medical Chemistry, 30, 1891-1896.

RiboCeine - The Unparalleled Anti-Aging Technology that Empowers You to Live Younger, Feel Better, and Perform Stronger!


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Cautions – The Fake Glutathione Supplements Industry…

The thing about raising glutathione levels intracellularly, is it requires transporting a very fragile molecule called cysteine past the brutal stomach acid – in order for it to be effective. So if you’ve been buying glutathione supplements that don’t protect cysteine, you’ve basically been throwing your money down the drain. Not to mention creating some expensive yellow liquid waste along the way.

When most people realize glutathione pills don’t work, it’s understandable why they feel completely ripped off and angry. As unfortunately so far, there’s no law against marketing products that don’t work.

So when Max products was released to the masses, the first question people asked, was if it could in fact protect the cysteine molecule and deliver it intact/unharmed to the cells? And the answer is yes, thanks to Riboceine!

Protecting the cysteine molecule is not a minor detail, this is the difference between your body being able to make more glutathione – or not. When you read through the published peer reviewed articles behind the RiboCeine ingredient in Max products you’ll find there is no other product on the market that compares to its ability to support intracellular glutathione.


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The Health Benefits Of The D-Ribose In Riboceine

Riboceine is a very simple molecule that is 100% unique to Max International through Dr Nagasawa’s patents and patents pending. It’s ribose and cysteine and Riboceine is just a name that it’s been trademarked under. What we know is that Riboceine is about 300% more potent than NAC for actually helping the cells create glutathione.

What Is Ribose & What Do We Know About It?

L or D-ribose has to do with the shape of the molecule. In humans, D-ribose is the shape that has a physical effect – L doesn’t usually occur in that format. So when we say ‘D-ribose’ we really just mean Ribose. With Cysteine we call it L-cysteine and we really just mean cysteine.

Ribose was first identified in 1944, as a part of the structural component of DNA and RNA. That’s all we really knew about it back then. Though a lot of studies occurred in the 1950′s, it wasn’t until around around 1957 that a whole other activity for ribose was discovered that changed everything. And it had specifically to do with the production of energy within the cell.

So back in the day of first learning about Ribose, it was only really known that if you had it in your body, you’d be supporting the health of  your DNA and RNA. But that wasn’t the only benefit. The biggest physiological benefit has to do with the production of ATP (the packets of energy made within your cells), inside the mitochondria. Cells have many mitochondria, that absorb and break down nutrients needed to create energy for the cell. Some cells have hundreds of mitochondria, and some may have tens of thousands. It really depends on what that particular cell needs to do and how much energy it needs. E.g. a muscle cell will have more mitochondria than a cell that requires less energy.

In the process of making energy, complicated chemical things occur inside the mitochondria and molecules are hooked together to make ATP. Part of the actual molecule of ATP is ribose. In addition to that, glutathione also supports the production of ATP. Because if you don’t have enough glutathione inside the mitochondria, the production of ATP slows down due to the amount of free radicals created. And if your body can’t deal with those free radicals, the cell will be destroyed.

As you might imagine, if you are busy making a lot of ATP and you’re not replenishing the raw material to make it, it may be helpful to have more of that raw material. And part of that raw material is ribose. Your cells can make their own ribose (by breaking down glucose), but it takes a little bit of time to do that.

With Riboceine, Nothing Goes To Waste!

A component that is considered to be the rate limiting factor in the production of glutathione within our bodies is cysteine.
One of the challenges with the cysteine amino acid, is it’s fragile sulfhydryl group can easily be broken off as it goes through the digestive process. And you cannot make glutathione if you don’t have an intact sulfhydryl group. One way of protecting cysteine’s sulfhydryl group, is by wrapping it in an acetyl group, which is exactly what NAC (N-Acetyl Cysteine) does. With NAC, once your body delivers cysteine safely to the cell, it removes the protective Acetyl group and then just discards it as it doesn’t need it to do anything else. So essentially, we’ve just wrapped up something that we needed temporarily, with something that we don’t need.

What Dr Nagasawa was trying to figure out, was a way to potentially hook cysteine to another endogenous molecule (meaning a molecule that occurs within your cells anyway) in a way that it would 1. improve absorption & 2. create an opportunity for your cells to utilise the entire molecule. And he discovered that ribose did both of those things and more. It protected cysteine, is 100% utilised by the cell & provided other benefits for the health of the cell.

Ribose itself is highly absorbed from the intestinal track, so your body loves it & your cells are used to seeing it. What happens inside the cell, is at the time that there’s a demand for the cysteine to make glutathione, the molecule will separate and the cysteine is freed up to go be part of glutathione. So with Riboceine, the other half of it (ribose), does not go to waste.

What Studies Have Been Done On Ribose?

A lot of studies related to ribose, have looked at cardiac issues more than anything else.

There is a book written by a couple of cardiologists (Stephen Sinatra & James Roberts) called: Reverse heart disease now. Looking at some of the insights from their book, when Dr Roberts heard about d-ribose a light bulb immediately went off in his head. For some time he had been using L-carnitine & Coenzyme Q10 in his medical practice to boost energy metabolism in sick hearts. But neither of these could rebuild the metabolic energy pool once it had been depleted by heart disease. He wondered if d-ribose could be the missing link….

He decided to try it on himself first as he does a lot of exercise. And he found that with that, he definitely was improving from his stiffness and soreness afterwards much more quickly.

In his cardiology practice he offers patients an EECP program. Those of you who have ever had EECP, you know it’s not a very comfortable thing. It’s an external counter pulsation. So basically what it’s trying to do is from the outside of your body, push a little harder to help your heart to actually have more ‘oomph’ when it’s trying to pump blood. This is usually used for hearts that are quite weak and are unable to really pump blood very effectively. It’s almost like an external massage type of thing to help your heart pump better. It’s a non invasive method that restores the flow of oxygenated blood in patients with recurrent or inoperable coronary artery disease.

Before d-ribose, most of the patients on EECP experienced good improvement. However after adding d-ribose, improvement made a quantum leap from good to great. In hard core cases like these, supplying oxygen alone to the chronically heart deprived heart cells is not enough. Yes the cells are deficient in CoQ10 and l-carnitine quite possibly, but above all they lacked the precursors of ATP.

The reality is, what they actually lacked was glutathione. But this doctor wasn’t aware of glutathione – which is not uncommon.

So as he began to use d-ribose on his patients, here is some of what he found:
 

“Ischemia (which means decreased blood flow) may cause the heart to lose up to 50% of its ATP pool. Even if blood flow and oxygen are restored to normal levels, it may take up to 10 days for an otherwise healthy animal heart to rebuild cellular energy and normalize diastolic cardiac function. In studies, when oxygen-starved animals receive d-ribose, energy recovery and diastolic function return to normal in an average of two days. When patients with coronary artery disease are treated with d-ribose, symptoms and treadmill time improve significantly within one week.”

Here’s a summary of a landmark study that was also specifically looking at ribose 
 

“The cardiac arrest induced during certain kinds of heart surgery such as bypass surgery cause heart muscle function to deteriorate quickly. Even in relatively healthy areas of the heart an effect that is associated with low ATP levels which can severely delay recovery following surgery. As a result scientists administered Ribose to the heart during surgery reasoning that they could stoke up heart muscle in advance with the necessary ingredients for making ATP. This procedure produced dramatic results in the experimental study consisting of a full hour of cardiac arrest. The ribose-supplemented experimental group showed significant improvement in heart muscle function compared with controls—and the amount of improvement correlated directly with the quantity of ATP in the heart muscle!”

So even in the medical world, they are beginning to integrate things like ribose to support cardiac function.

By the way when you look at ribose for cardiovascular benefit, it goes back to the 1980′s. Which is really interesting too because again Dr Nagasawa first published work on riboceine in 1987. His focus was liver health and cysteine (which is part of glutathione and critical for the health of the liver) and other people were focused on the ribose side of things.




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RiboCeine - Glutathione production to the max

Glutathione (GSH) is produced by every cell in your body. It is the primary protector and detoxifier of the cell. For years, scientists and medical professionals have looked for ways to effectively raise glutathione levels. Because glutathione cannot be effectively absorbed through the intestinal tract, it must be supplemented via its essential building blocks, the amino acids cysteine, glycine, and glutamic acid. While glycine and glutamic acid are readily available through regular diet, it is much more difficult to absorb the required amounts of cysteine. Until recently, N-acetyl Cysteine (NAC) was the most consistent means of enhancing the body's ability of maintaining optimal glutathione levels. To be effective, NAC supplementation required large steady doses that could be inconvenient and overly expensive.

Now, thanks to RiboCeine, the game has changed.

Optimal amounts of glutathione

RiboCeine has been shown to effectively deliver cysteine into the cell, enabling it to produce optimal amounts of glutathione. Unlike any other nutritional compound in the world, RiboCeine has been the subject of twenty published, peer-reviewed scientific studies that were funded by the National Institutes of Health and other scientific institutions. RiboCeine was developed after years of research by the renowned research scientist and medicinal chemist, Herbert T. Nagasawa, Ph.D.

Herbert T. Nagasawa Ph.D.

Dr. Nagasawa was a Professor of Medicinal Chemistry and Toxicology at the University of Minnesota for forty years and at the same time he was named Senior Career Research Scientist for the Veterans Administration Medical Center in Minneapolis. For thirty-two of those years he was Senior Editor of the Journal of Medicinal Chemistry. Dr. Nagasawa is driven to research ways to help humanity by improving health and wellness. A prolific researcher and author with 165 peer-reviewed and published clinical studies, Dr. Nagasawa has received millions of dollars in funding from some of the most respected health research institutions in America. The culmination of his personal drive and years of research and experience is RiboCeine.

RiboCeine outperforms others

RiboCeine combines Ribose and Cysteine, nutrients that are naturally occurring in humans, to more effectively deliver cysteine directly to your cells. This groundbreaking compound is a demand-release nutrient, activated by the body's cells. RiboCeine enters the bloodstream and is then used by the body to produce glutathione, the body's master antioxidant, and ATP, the cell's natural fuel and source of energy. Unsurpassed in effectiveness, RiboCeine has significantly outperformed all other means of glutathione enhancement against which it has been tested.


View - RiboCeine Peer-Reviewed Studies




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IV Glutathione Vs Glutathione Pills

One of the most popular forms of glutathione therapy in recent years, has become the administration of IV glutathione into the bloodstream. While there are some immediate & short term benefits from having a powerful antioxidant like glutathione circulating, the cell doesn’t have a receptor to receive it. And even though IV glutathione has been available for a number of years, it still remains very expensive.

On top of this, within a few days intravenous glutathione is processed out of the body, providing little to no long-term impact. These short term effects mean that in order to maintain or raise glutathione levels, several injections per week would be needed. And at over $100 per injection, this makes it cost prohibitive for most people. In addition to the cost, although intravenous glutathione does boost blood serum glutathione levels, it’s unclear as to how much of that actually gets inside the cell. It is most likely quite a small amount, because the molecule is too large to cross the cell walls and get into the cell, where it belongs and does it’s best work.

While IV glutathione therapy has become popular for many different reasons, the reality is the benefits have a very short life span. Long term results are better achieved by providing your body with the precursors, so that it can make it naturally.

Do Glutathione Pills & Supplements Work?

While you can buy glutathione pills, scientists and researchers have known for quite some time, that supplementation with whole glutathione makes little – to no difference at all. It’s well documented that glutathione available in supplement form, is mostly destroyed through the digestive process. Therefore it is of little to no use, unless it can penetrate the cell walls. A few other glutathione products have been marketed as supplements & patches, but all have made only a very small impact as far as raising glutathione levels intracellularly.

Will Whey Protein Raise My Glutathione Levels?

With oral supplementation, the best you could do was whey protein. A number of glutathione stimulators use high doses of un-denatured whey protein to provide the amino acid cysteine, which necessary for glutathione production. If you take enough of it (several thousand calories a day), you might boost your glutathione levels somewhere between 10% to 40%. Which is better than nothing. But you’re also having to deal with a huge caloric intake and drinking a LOT of whey protein, which is not a very practical solution. In summary, glutathione supplements don’t have any value of any appreciable nature, so are pretty much a waste of time.

Your body has an amazing ability to heal itself. When you provide it with the correct resources, it knows exactly what to do with them. So in the case of raising glutathione levels, what it really needs are the building blocks (the correct ingredients) so it can do what it knows best. Which is to create this molecule naturally, inside it’s own cell.




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Glutathione Benefits

Glutathione has been described as the greatest antioxidant that you didn’t know existed. Glutathione is not only a powerful antioxidant itself, but also acts to recycle other antioxidants for maximal function. Antioxidants are critical in negating the harmful effects of reactive oxygen species such as free radicals and peroxides. These harmful molecules can cause oxidative stress on the body’s cells, which may damage or kill these cells. In fact, oxidative stress has been associated with over 74 major diseases and disorders.

Hence, antioxidants are critically important in maintaining a healthy body, and Glutathione is critical in maintaining appropriate levels of antioxidants. However, this is just one of the numerous Glutathione benefits, with more functions of this important molecule being discovered every day. This article aims to provide an overview of the currently recognised Glutathione benefits, and outlines the importance of Glutathione in normal, healthy functioning of the body.


Glutathione Plays Many Important Roles

Glutathione is found in almost every cell in the body, and as a result of this it has a wide variety of roles throughout the body. Glutathione plays important roles in the following areas:

Lungs – The epithelial cells lining the lungs utilize Glutathione to protect against oxidative stress. A chronic infection, smoking or inhaled pollutants can cause the depletion of this protective layer, resulting in inflammation, lung damage and even lung disease.

Brain – Glutathione decreases oxidative stress in the brain, and is known to be depleted in the brains of people with Parkinsons Disease, depression, autism spectrum disorders, ADHD and other neurological diseases. Glutathione has also been shown to improve mental clarity and memory, as well as helping prevent the formation of amyloid plaques in the brain that lead to Alzheimers Disease.

Cellular detoxification – In the industrial world we live in today, we are exposed to over 80,000 chemicals in the air we breathe and the food and water we ingest. Many of these chemicals are toxic and enter our cells, and must be eliminated to protect the cell and maintain optimal function. Glutathione is the cell’s primary defence against chemicals and toxins, and works to eliminate these from our bodies.

Immune system protection – Glutathione facilitates the proliferation of newly formed immune cells. It also has properties which aid in the protection of the body from viruses, and is a significant mediator of inflammation. While some inflammation is beneficial in controlling infection, too much can have dire consequences and lead to autoimmune diseases, rheumatoid arthritis, diabetes, multiple sclerosis and many more harmful diseases.

Fertility – Glutathione is the essential molecule that allows the sperm and the egg to fuse at conception. Research has indicated that low Glutathione levels may be linked to infertility and complications during pregnancy.

Eye health – The Glutathione content in the eye is relatively high, and the molecule plays an important role in maintaining the transparency of the lens. Other Glutathione benefits in the eye include assisting in the prevention of cataracts, glaucoma, retinal disease and diabetic blindness.
These are but some examples of the currently recognized Glutathione benefits. It is plain to see that this molecule is exceptionally important for normal cellular function and protection from a myriad of diseases, regardless of where in the body it is being used. As we are exposed to even more chemicals through new packaged foods, new agricultural methods and larger cities with more pollutants, Glutathione becomes even more important.

Unfortunately, Glutathione levels do decline over time with age and exposure to a variety of toxins. Alcohol consumption, a diet high in processed foods, stress and trauma, chronic illness and other conditions can all impact your Glutathione levels and reduce the ability of Glutathione to perform its beneficial functions.

Staying healthy and exercising regularly, avoiding stress where possible, getting plenty of sleep and enjoying a diet rich in fresh fruit and vegetables all help to maintain your Glutathione levels and allow you to experience the many important Glutathione benefits.




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Glutathione - The Master Molecule

Glutathione (GSH) is your body's master antioxidant, it is a small molecule produced naturally in the body if the required building blocks are available. Glutathione strengthens the immune system, detoxifies the body, fights intracellular inflammation, and neutralizes numerous types of free radicals. Toxins and free radicals damage your cells thereby accelerating the aging process along and making you more susceptible to ailments and other issues associated with aging.

Body's use of Glutathione

The cells in your intestinal tract use glutathione to try to eliminate the chemical preservatives, pesticides and countless other toxins you ingest before they are transported throughout your body. The liver cells use glutathione as their detergent to detoxify your blood. Your eye and skin cells use glutathione to protect themselves against radiation. Glutathione helps your body defend against oxidative stress, which has been associated with more than 74 major diseases and disorders. Simply put, without glutathione, oxygen-based life on earth would be impossible.



 

Over 100,000 scientific studies

Over 100,000 scientific studies and articles on glutathione are recorded in PubMed, the official U.S. Government library of medical research. Those articles reveal the remarkable role glutathione plays in the protection and function of every cell, organ, and tissue in the human body and the support of optimal health and function. They also show the terrible consequences of low glutathione levels, and how those lower levels accelerate the aging process and increase vulnerability to the issues of aging.

The effect of low glutathione

Modern research has shown that individuals who have low levels of glutathione have a high association with illness. Unfortunately, decreased levels of glutathione can be brought about by continual stress upon the immune system. This is a ferocious cycle. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione. Various daily activities can also reduce your glutathione levels such as stress, exercise, infection, injury, poor diet, and environmental toxins. Your glutathione, or in other words, your body's natural defense against aging and cellular damage starts to decline as you age, decreasing by about 10% to 15% every decade! 

The future of glutathione

In the near future the importance of glutathione will be widely recognized because of the vital role it plays in your daily and long-term health. Max International is committed to leading the way in educating about its importance. 

Glutathione FAQ

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