Behcet's Disease

Behçet’s disease (BD), first described by a Turkish physician, Hulusi Behçet, is a chronic, progressive disorder that affects many systems of the body, including the eye. Common manifestations include oral and genital ulcers, skin lesions, and uveitis, which may cause blindness. Involvement of the gastrointestinal tract, central nervous system, and vascular system is less common but accounts for mortality associated with BD disease.

Oxygen free radicals and lipid peroxides have been implicated in the pathogenesis of numerous diseases such as diabetes mellitus, cancer, rheumatoid arthritis, systemic lupus erythematosus, infectious diseases, atherosclerosis, and in aging. Growing evidence indicates that oxidative stress is increased in BD, owing to overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defences, including the master antioxidant glutathione. (Ref: Taysi et al, Antioxidant Status in Patients with Behcet's Disease, 2002)

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"GST are a family of proteins that play an important role in the prevention of toxic injuries in various tissues. Patients with Behcet’s Disease (BD) showed a higher prevalence of the GSTM1-null genotype than the healthy individuals (41.1% and 24.2% respectively). In spite of an unknown etiology, it is now accepted that reactive oxygen species produced by neutrophils may be related to the pathogenesis of BD. Toxic compounds such as pesticides and insecticides have been incriminated in BD." ~ Tursen et al, Arch Dermatol Res 2004

Glutathione is able to neutralise oxidative stress and detoxify toxic chemicals from the body. It is known that patients with Behcet's Disease (BD) have depleted levels of glutathione, but in practice it can be difficult to effectively increase systemic glutathione levels, as glutathione (GSH) is a fragile molecule that is quickly broken down in the digestive system if taken by mouth. Glutathione must be synthesised within the cell because it cannot be transported into cells.

The glutathione prodrug RiboCeine™ delivers the essential precursor nutrients (ribose and cysteine) to the cell where they can then be turned into glutathione and energy in the form of ATP. RiboCeine has received extensive scientific validation in published peer-reviewed studies and has been shown to significantly increase intracellular glutathione.

Advanced nutritional supplement Cellgevity™ contains RiboCeine™ in combination with a selection of synergistic antioxidant and flavonoid ingredients, including resveratrol, quercetin, alpha lipoic acid, selenomethionine and curcumin.




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